Automated instrument for ‘gold standard’ measurement of ionization (pKa), lipophilicity (LogP/D) and Solubility using sub milligram sample quantities.

The SiriusT3 is the next generation physchem measurement system from Sirius Analytical. It is the successor to our world renowned and market leading GLpKa and ProfilerSGA systems, which over the last decade have been established as the industry standard for pKa, logP/D and solubility determinations by automated potentiometric and spectroscopic titration.

SiriusT3 key features and benefits:

• pKa, logP, logD and pH-Solubility profiling integrated on a single system
• Full automation – no manual moving or cleaning of probes required
• 1ml assay volume, less than 1mg of sample required
• Minimal running costs – uses off the shelf reagents with no special “kits” required
• Fully automated cosolvent assays included as standard
• Automatic calibration and cleaning protocols
• Built-in automatic turbidity detection – precise detection of precipitation events
• Computer controlled temperature management – no water circulator required!
• Measure under physiologically relevant conditions
• Study effects of solvents, excipients, additives, biorelevant media
• Built in ultra-sonic bath to aid measurements of insoluble compounds
• pH range of 1.8 – 12.2, extendable to 0.5 to 13.5 with UV options
• Powerful software can model effects of ionization, partitioning, precipitation and solvent shifts – no data is wasted!