The discovery and development of a new drug entity (NDE) is a complex, costly and time-consuming process, in which chemical resynthesize is an essential procedure after library screening. If one of the substances shows enough activity to be further investigated, it should be resynthesized to provide enough quantities (up to several grams) for activity verification and structure optimization, further to pass all necessary tests such as toxicological test and ADME researches in preclinical development.

Traditionally, chemical synthesis is the main source of new structural classes for biological testing in drug discovery. Chemical synthesis is the purposeful execution by physical and chemical manipulations usually involving various reactions in order to get a target product, or several products. In modern laboratory usage, a large number of rigorous and meticulous works are required to make sure that the process is reproducible and reliable.