Chiral resolution, as an important tool in the production of optically active drugs, is a process for the separation of racemic compounds into their enantiomers in the aspect of stereochemistry. The present special issue on chiral resolutions carries papers covering a wide range of techniques and classes of compounds. The technical issues surrounding product development, particularly in the pharmaceutical industry, have acquired significant importance with the current environment of increased regulatory requirements that exist for drug products with stereogenic centres. Particularly when the methods of stereospecific synthesis designed for one of the enantiomers, at present, lead generally to enhanced enantioselectivity, not only the development of analytical methods for the chiral separation to control optical purity of a large number of pharmaceuticals/therapeutics, administered today, but also the development of methods for quantitative large-scale separation from their racemic or enantiomeric mixture are required and are the challenges for chemists and open wider perspectives for such developments.

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