Description & Specifications
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MHC tetramer is a complex of 4 MHC molecules associated with loaded peptide, which is bound to a fluorescently labeled streptavidin molecule. Monomeric MHC molecule is loaded with its cognate peptide, and biotin is linked to the complex at a site far removed from the T-cell recognition site. The monomeric MHC-peptide complexes bind to streptavidin, which further tightly binds biotin at 4 separate sites, thus making a tetrameric complex, the MHC tetramer. Creative Peptides is offering MHC tetramer synthesis with a set of peptide sequences customized by customers now. Here is a list of available alleles that Creative Peptides can provide. Currently two choices of fluorochrome labeling are available based on customer’s request: phycoerythrin (PE) or allophycocyanin (APC). Creative Peptides also provides clinical grade tetramer for our clients. These highly purified products can be used in immunotherapy trials. https://www.creative-peptides.com/services/custom-mhc-peptides-tetramer-service.html |