Description & Specifications
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Peptide stapling is a strategy for constraining short peptides typically in an alpha-helical conformation. Stapling is carried out by covalently linking the side-chains of two amino acids, thereby forming a peptide macrocycle. Peptide “stapling†via interside-chain hydrocarbon linkages has emerged as one of the most promising approaches for the generation of potent and stable type â… peptidomimetics of α-helical protein binding motifs. Once inside the cell, stapled peptides are stable, and able to initiate or inhibit protein-protein interactions that are useful for the treatment of cancer, insulin secretion, inflammation and many other disease states. Creative Peptides has extensively developed stapled peptide structures and is the company of choice to manufacture your stapled peptide requirements, providing a confidential and efficient service at competitive prices. Every step of peptide synthesis is subject to Creative Peptides’ stringent quality control. Typical delivery specifications include: • HPLC chromatogram • Mass spec analysis • Synthesis report • Certificate of Analyses |